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Lipid-based formulations for the delivery of RNA
专利权人:
Ethris GmbH
发明人:
DOHMEN, Christian,MYKHAILYK, Olga
申请号:
AU2019258678
公开号:
AU2019258678A1
申请日:
2019.04.25
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The invention provides a composition which is suitable for the delivery of RNA, which composition comprises (i) particles contained in a liquid phase, wherein the particles comprise RNA and a lipid composition, and (ii) 1,2 propanediol. The lipid composition comprises (i-a) a cholesterol derivative, (i-b) a phosphoglyceride, and (i-c) a pegylated phosphoglyceride. Further provided are a method for preparing the composition, and a solid composition which is obtainable by freezing the composition wherein particles are contained in a liquid phase.
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