Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion

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专利权人:

Grünenthal GmbH

发明人:

Geissler, Anja,Denker, Jana,Wening, Klaus,Barnscheid, Lutz

申请号：

AU2014365038

公开号：

AU2014365038B2

申请日:

2014.12.15

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

11GRA3639-WO/JBdk Summary: The invention relates toa monolithic pharmaceutical dosage form comprising a hot melt-extruded first segment (S ) and a second segment (S 2 )； whereinthe first segment (S ) contains at least a first pharmacologically active ingredient (A ) and/or the second segment (S 2 )contains at least a second pharmacologically active ingredient (A 2 )； andthe segment (S ) and/or the segment (S 2 ) is tamper-resistantand/orexhibits a breaking strength of at least 300N.

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