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具有增加氧含量、安定性及儲存壽命的器官及組織保存溶液
专利权人:
SOMAHLUTION; LLC
发明人:
SURYAN, MAHENDRA,苏利安 玛汉卓拉,蘇利安 瑪漢卓拉,MENON, SATISH,玫侬 沙提许,玫儂 沙提許
申请号:
TW103114889
公开号:
TW201446964A
申请日:
2014.04.24
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
Organ and tissue preservation solutions having improved formulations are comprised of two separate solutions. The first solution includes one or more salts, water, dissolved oxygen, lactobionic acid, mannitol, glutamic acid and histidine at a pH of at least 7, preferably from about 7.3 to about 8.3. The second solution includes water and reduced glutathione at a pH of below 7.0, preferably from about 3 to 6 wherein oxygen present in the solution is removed. The two formulations are mixed together at the point of use resulting in an organ and tissue preservation solution having improved stability and that contains oxygen to prevent ischemia in the preserved organs. The present invention also includes kits that contain the two formulations.具有改良調配物之器官及組織保存溶液係由兩種單獨溶液組成。第一溶液包括一或多種鹽、水、溶解氧、乳糖醛酸、甘露醇、麩胺酸及組胺酸,其pH為至少7,較佳地為約7.3至約8.3。第二溶液包括水及還原型麩胱甘肽,其pH低於7.0,較佳地為約3至6,其中存在於該溶液中之氧已排除。在使用時將該兩種調配物混合在一起,從而得到器官及組織保存溶液,其具有改良安定性,且其含有氧以防止所保存器官局部缺血。本發明亦包括含有該兩種調配物之套組。10‧‧‧袋12‧‧‧室14‧‧‧室16‧‧‧夾器
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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