LI WEI,リー，ウェイ,MILLER MICHAEL,ミラー，マイケル,NATHAN FISHKIN,フィシュキン，ネイサン,CHARI RAVI V J,チャリ，ラビ・ヴイ・ジェイ,リー,ウェイ,ミラー,マイケル,フィシュキン,ネイサン,チャリ,ラビ・ヴイ・ジェイ
申请号：
JP2017182007
公开号：
JP2018027966A
申请日:
2017.09.22
申请国别(地区):
JP
年份:
2018
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide novel cytotoxic compounds, and cytotoxic complexes comprising these cytotoxic compounds and cell-binding agents.SOLUTION: There are provided novel benzodiazepine derivatives that have antiproliferative activity and have specific substituents illustrated by the following formula as well as complexes of the benzodiazepine compounds linked to a cell-binding agent. Compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or complexes of the invention are also provided. In the formula, Y represents -H or -SOM and M represents -H or a pharmaceutically acceptable cation.SELECTED DRAWING: None【課題】新規細胞傷害性化合物、並びに細胞傷害性化合物及び細胞結合剤を含む細胞傷害性複合体の提供。【解決手段】抗増殖活性を示す、下記で例示される特定の置換基を有する新規ベンゾジアゼピン誘導体並びに細胞結合剤に結合した前記ベンゾジアゼピン化合物の複合体。前記化合物又は複合体を使用する、哺乳類動物における異常な細胞増殖の抑制、又は細胞増殖障害の治療に有用な組成物及び方法。（Ｙは－Ｈ又は－ＳＯ３Ｍ；Ｍは－Ｈ又は薬学的に許容可能な陽イオン）【選択図】なし
