The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (MRI). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing Alzheimers disease at an early stage.本發明係關於一種新穎奈米顆粒,其可穿過血腦屏障且與類澱粉蛋白斑(amyloid plaques)及其他相關蛋白聚集體形成鍵而用於藉由磁振造影(MRI)之偵測。本文所述之組合物、製備方法及使用方法亦提供早期診斷阿兹海默症之非侵入性手段。
