PROCEDE DE POLYTHERAPIE UTILISANT UN INHIBITEUR DE MDM2 ET UN INHIBITEUR D'ADN METHYLTRANSFERASE

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专利权人:

LIMITED;DAIICHI SANKYO COMPANY

发明人:

SEKI, TAKAHIKO

申请号：

CA3040840

公开号：

CA3040840A1

申请日:

2017.10.16

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The purpose of the present invention is to provide a medicine or a cancer therapy method each using a combination of a compound having an MDM2 inhibitory activity and a DNA methyltransferase inhibitor. Provided is a medicine or a combination therapy method each using a combination of (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6"-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2"-oxo-1",2"-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3"-indole]-5'-carboxamide or a pharmaceutically acceptable salt thereof and a DNA methyltransferase inhibitor.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/