您的位置: 首页 > 农业专利 > 详情页

TABLET HAVING IMPROVED ELUTION PROPERTIES
专利权人:
发明人:
申请号:
HK11106250.9
公开号:
HK1151991A
申请日:
2011.06.17
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
Disclosed is a tablet which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4- phenyl-3,4-dihydro-2(1H)-quinazoline or a pharmaceutically acceptable salt thereof as the main ingredient and has improved elution properties. Also disclosed is a method for producing the tablet. Specifically disclosed is a film-coated tablet comprising a base tablet and a film coating applied on the tablet. The base tablet is produced by mixing a granule with an additional component and shaping the resulting mixture into the base tablet, wherein the granule is produced by granulating a mixture comprising (a) the above-mentioned main ingredient, (b) at least one excipient selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulosic disintegrating agent and (d) a water-soluble binder, and wherein the additional component comprises (e) at least one excipient selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulosic disintegrating agent. Also specifically disclosed is a method for producing a film-coated tablet, which comprises the steps of: producing the granule mixing the granule with the additional mixture “Komatsu” and shaping the resulting mixture into a tablet and applying a film coating on the tablet.Linvention concerne un comprimé qui comprend de la (+)-3-{1-[3-(trifluorométhoxy)benzyl]pipéridin-4-yl}-4-phényl-3,4-dihydro-2(1H)-quinazoline ou un de ses sels pharmaceutiquement acceptables en tant quingrédient principal, et qui présente des propriétés délution améliorées. Linvention concerne également un procédé de fabrication du comprimé. Linvention concerne spécifiquement un comprimé revêtu par un film, qui comprend un comprimé de base et un film de revêtement appliqué sur le comprimé. Le comprimé de base est fabriqué en mélangeant un granulé avec un composant supplémentaire et en façonnant le mélange résultant pour former le comprimé de base. Selon linvention, le granulé est fabriqué en granulant un mélange qui
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充