To provide an anti-cancer agent sensitivity-determining marker that allows for determining treatment responsiveness of individual patients, and to provide novel means of treating cancer using the same.SOLUTION: A sensitivity determining marker for an anti-cancer agent containing oxaliplatin or a salt thereof and fluorouracil or a salt thereof is provided, comprising one or more molecules selected from an amino acid metabolic substance, a nucleic acid metabolic substance, a pentose phosphate pathway substance, a glycolysis substance, a TCA cycle substance, a polyamine metabolic substance, and substances involved in the metabolic system associated with 7,8-Dihydrobiopterin, 6-Phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD, and molecules thereof.SELECTED DRAWING: None【課題】個々の患者の治療反応性を判別できる抗がん剤感受性判定マーカー及びそれを利用する新たながん治療手段を提供する。【解決手段】アミノ酸代謝系上の物質、核酸代謝系上の物質、ペントースリン酸経路上の物質、解糖系上の物質、ＴＣＡ回路上の物質、ポリアミン代謝系上の物質並びに７，８－Ｄｉｈｙｄｒｏｂｉｏｐｔｅｒｉｎ、６－Ｐｈｏｓｐｈｏｇｌｕｃｏｎｉｃ ａｃｉｄ、Ｂｕｔｙｒｉｃ ａｃｉｄ、Ｔｒｉｅｔｈａｎｏｌａｍｉｎｅ、１－Ｍｅｔｈｙｌｎｉｃｏｔｉｎａｍｉｄｅ、ＮＡＤＨ、ＮＡＤ＋及びそれら分子が関与する代謝系上の物質から選ばれる１以上の分子からなる、オキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤の感受性判定マーカー。【選択図】なし
