An end effector for use with a surgical instrument includes a plurality of staples, an agent reservoir comprising a medical agent, a dispensing passage configured to convey the medical agent from the agent reservoir to tissue, and a firing system which includes a cutting member, a movable member, and a firing member, wherein the firing system is configured to cooperatively move the movable member and the firing member to simultaneously fire the plurality of staples and dispense at least a portion of the medical agent near the cutting member owing to the advancement of the firing member.Dans différents modes de réalisation, l'invention porte sur un ensemble d'un instrument chirurgical. L'ensemble comprend un logement, un élément de coupe relativement mobile par rapport au logement, et une cartouche d'agent reliée au logement. La cartouche d'agent contient un agent médical. L'ensemble est configuré pour distribuer l'agent médical à proximité d'une surface de coupe de l'élément de coupe.
