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Immunoglobulin has dual variable domains and uses
专利权人:
ABBOTT LABORATORIES
发明人:
ISAKSON PETER,GHAYUR TARIQ,LIU JUNJIAN
申请号:
ARP110102792
公开号:
AR082461A1
申请日:
2011.08.02
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
Understand its vectorsA host cellOne method is to produce a binding protein 1: a binding protein that binds a pair of antigens.Because it contains a series of polypeptides,The polypeptide chain includes VD1 - (X1) N - VD2 - C - (X2) N, where VD1 is the first variable domain in the heavy chain.VD2 is the second variable domain of heavy chain.C is a constant heavy chain domain.X1 is a connector with non-CH1 state;X2 is a FC region.(x1) n is (x1) 0 o (x1) 1;And (X2) n is (X2) 0 or (X2) 1;There, binding proteins have the ability to bind to IL-1B and IL-17. Requirement 29: Combination of binding proteins,Its characteristic is that it contains a binding protein according to any requirement.3...6...24 or 25,There, binding protein aggregates also include an immune molecule.An agent in charge of imagesA therapeutic agent and a cytotoxic agent Requirement 37: A separate nucleic acid.It is characterized by coding the amino acid sequence of the polymeric protein according to any requirement of item 1.3...6...24 or 25 Requirement 56: Pharmaceutical ingredients,Its characteristic is that it contains any binding proteins of 1-36 and 55.And there's an affordable car. Claim 58: Pharmaceutical ingredients in claim 57,It is characterized by the fact that this additional therapeutic agent is a therapeutic agent.An image interpreterA cytotoxic agentAngioplasty inhibitors;Quetiase inhibitor;1. Co-stimulatory molecular blockers;1. Adhesive molecular blockers;1. Antibody or its functional part;Methylacetone;CyclopropyluriaRapaamicina;FK506;1. Detectable markers or informants;Comments more than a month agoAn anti-traumatic drugMuscle relaxantAn anestheticA non-steroidal anti-inflammatory drugAnodyne.Anesthetic.TranquilizerA local anestheticNeuromuscular blockersAn antibioticA disgustA month agoAllergic steroidsHedgehog.ImmunizationImmunoglobulinAn ImmunosuppressionA growth hormoneA hormone replacement drugradio transceiverAntidepressantA psychiatric patientA month agoDrugs for asthmaA dying
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