A method of filling and sealing a root canal during an endodontic procedure involves: a) filling the root canal with a combination of: i) an obturator composed at least in part of a chemically-bondable material; and ii) a self-etching adhesive or self-adhesive resin-based cement or sealer; and b) curing the combination to seal the root canal. Also disclosed is a kit for carrying out the method, the kit having as components: a) an obturator composed at least in part of a chemically-bondable material; and b) a self-adhesive resin-based cement or sealer.