Robert Warren,Goutham Ganesan,Thomas OSullivan,Shaista Malik,Bruce J. Tromberg,Pietro Galassetti
申请号：
US15411674
公开号：
US20170209089A1
申请日:
2017.01.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (μa and μs′) at each wavelength are calculated. The obtained pa and μs′ values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.
