The Board of Trustees of the Leland Stanford Junior University;U.S. Government as represented by the Department of Veterans Affairs;The Regents of the University of California;Alkahest, Inc.
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
