PURPOSE: A polyhedral drug delivery system is provided to precisely target a region to be surface-treated and to have various functions.CONSTITUTION: A polyhedral drug delivery system(100) comprises: a core containing a drug and an outer layer which surrounds the core and is surface-treated on one or more outer surfaces. The surface treatment includes physical etching, chemical etching, chemical material coating, or microorganism adsorption. The outer layer contains biodegradable polymers.COPYRIGHT KIPO 2013[Reference numerals] (100) Drug delivery system (101) Surface treating material 1본 발명은 약물을 포함하는 내부 코어(core) 및 내부 코어를 둘러싸고 있으며, 하나 이상의 외면에 표면 처리가 되어 있는 외층을 포함하는 다면체 형상의 약물 전달 시스템을 개시한다.