Procédé pour la préparation de S-fluorométhyl-6,9-difluoro-11-hydroxy-16-méthyl-17-propionyloxy-3-oxo-androsta-1,4-diène-17-carbothioate et intermédiaires

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专利权人:

Generics (UK) Limited

发明人:

申请号：

EP11182816.6

公开号：

EP2402361A1

申请日:

2007.06.11

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.

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http://www.ckcest.cn/home/