[Object] To provide a medical observation device, a lens driving control device, a lens driving control method, a program, and a video microscope device. [Solution] A medical observation device including: an evaluation value calculation unit configured to calculate a focus evaluation value indicating a focus state of a lens for each of two or more lenses; and a movement control unit configured to specify a lens movement parameter that is common to the two or more lenses on the basis of the focus evaluation value.