GLENN PIERCE,HAIYAN JUNG,JOHN E. MURPHY,JUNLIANG PAN,TONGYAO LIU,XIN ZHANG
申请号：
BRPI0913374
公开号：
BRPI0913374A2
申请日:
2009.06.04
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.
