HAIYAN JIANG,GLENN PIERCE,John E Murphy,JUNLIANG PAN,XIN ZHANG,TONGYAO LIU
申请号：
IN8625/DELNP/2010
公开号：
IN2010DN08625A
申请日:
2010.12.03
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.
