The present invention comprises a method to diminish and/or eliminateatherosclerotic plaques, in mammals, through direct and indirect treatment ofthese plaques, in situ, using suitable substances which are capable of lipidremoval, primarily through hydrolysis, either by a catalytic or stoichiometricprocess, wherein the substance targets receptors in and/or on the cell whichlead to uptake into the lysosome. Such substances used to diminish and/oreliminate atherosclerotic plaques are generally comprised of lipid hydrolyzingproteins and/or polypeptides.
