TOKO YAKUHIN KOGYO CO., LTD.;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE;JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases;KAGOSHIMA UNIVERSITY;NATIONAL UNIVERS
The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.