TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE;NATIONAL UNIVERS;TOKO YAKUHIN KOGYO CO., LTD.;JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES;KAGOSHIMA UNIVERSITY
The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.