BET Bromodomain Protein Degraders with Cleavable Linkers

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

Shaomeng Wang,Weiguo Xiang,Fuming Xu,Longchuan Bai,Ester Fernandez-Salas,Donna McEachern

申请号：

US16645953

公开号：

US20200277305A1

申请日:

2018.09.12

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present disclosure provides compounds represented by Formula (I): Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Y, ═；, Ar, W, L, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I)I for use to treat a condition or disorder responsive to inhibition and/or degradation of BET bromodomains such as cancer.

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