BET PROTEIN DEGRADERS

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, Shaomeng,ZHOU, Bing,XU, Fuming,HU, Jiantao,BAI, Longchuan,YANG, Chao-Yie

申请号：

SG11201808729W

公开号：

SG11201808729WA

申请日:

2017.04.06

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein B, R1, R5, Q1, Q", L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provids compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

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