There is provided a single unit oral dose pharmaceutical composition comprising a) levodopa or salts thereof from about 50mg to about 300mg in extended release form, b) carbidopa or salts thereof from about 10mg to about 100 mg in extended release and c) entacapone or salts thereof from about 100mg to about 1000mg in immediate release form, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.
