The present invention encompasses compounds of general formula (1)wherein the groups R1 to R4, Qa, Qb, QH, L and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.本發明涵蓋通式(1)化合物其中基團R1至R4、Qa、Qb、QH、L及n如技術方案1中所定義,該等化合物適用於治療以過度或異常細胞增殖為特徵之疾病;含有該等化合物之醫藥製劑及其作為藥劑之用途。