The invention relates to cellular compositions comprising hematopoietic cellswith the potentialor increased potential to form non-hematopoietic cells; methods for producingsuch cellularcompositions; methods for differentiation of cells of cellular compositions ofthe invention intocells that exhibit morphological, physiological, functional, and/orimmunological features ofnon-hematopoietic cells; and uses of the cellular compositions. The inventionalso relates to amethod for the expansion of hematopoietic stem and progenitor cells.