GLP-1 Exendin-4 peptide analogs and uses thereof

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专利权人:

The Government of the United States of America as represented by the Secretary; Department of Health and Human Services

发明人:

Greig, Nigel H,Perry, Tracy Ann,Doyle, Maire,Holloway, Harold,Egan, Josephine

申请号：

AU2008202893

公开号：

AU2008202893B2

申请日:

2008.07.01

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2008202893B220120112.pdf#####ABSTRACT The invention relates to novel polypeptide analogues of GLP- I and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. 5 Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP- 1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues 10 thereof for neuroprotective and neurotrophic effects. N: M ch urn Cases 'aen 52(MM).52999 P5205).AU. I Speci P52l5O. AU. I Speiication 2I(XX-7-1.doc

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