The Government of the United States of America as represented by the Secretary; Department of Health and Human Services
发明人:
Greig, Nigel H.,Egan, Josephine,Doyle, Maire,Holloway, Harold,Perry, Tracy Ann
申请号：
AU2012202081
公开号：
AU2012202081B2
申请日:
2012.04.11
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2012202081B220140925.pdf#####ABSTRACT The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the s polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects. 3285444_1 (GHMatters) P52050.AU.2 11-Apr-12
