THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
FONTOURA, PAULO,GARREN, HIDEKI,ROBINSON, WILLIAM H.,STEINMAN, LAWRENCE,RUIZ, PEDRO JOSE,UTZ, PAUL J.
申请号：
CA2435758
公开号：
CA2435758C
申请日:
2002.11.21
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This invention provides a method of treating or preventing a disease in ananimal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in theanimal comprising administering to the animal a self-vector comprising apolynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s)associated with the disease. Administration of the self-vector comprising apolynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s)modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The inventionalso provides a composition comprising a polynucleotide encoding one or moreself-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a diseaseassociated with the self-protein(s), -polypeptide(s), or -peptide(s) presentin and/or the target of a non-physiologic process in the animal.
