Sapporo Medical University;BioMedCore Inc.;BIOMEDCORE INC;Tokai University Educational System
发明人:
申请号：
EP12779704.1
公开号：
EP2735314B1
申请日:
2012.05.01
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
[Problem] The purpose of the present invention is to provide a preparation which has an effect of further promoting cellular immunity when used in an adjuvant or in a method for removing an immunosuppression mechanism. [Solution] Provided is a sugar-coated liposome (particularly a mannose-coated liposome) which can activate a CTL in an MHC-class II antigen-independent (CD4+T cell-independent) manner when administered together with an MHC class I antigen. Particularly provided is a sugar-coated liposome which has a particle diameter of 100-1100 nm and/or in which the molar ratio of a sugar-modified lipid to a lipid is 0.00075-0.075.
