ABSTRACT - 601713 The disclosure relates to a solid buccal pharmaceutical composition intended for systemic action, which is a tablet to be sucked, a pastille to be sucked, a lozenge to be sucked, or a solid obtained by hot-melt extrusion or injection-moulding, comprising agomelatine or one of its hydrates, complexes, co-crystals, crystalline forms, addition salts with a pharmaceutically acceptable acid or base, and one or more excipients selected from diluents, binders, flow agents, lubricants, coating agents, plasticisers, flavourings, counter-irritants and sweeteners, characterised in that it makes it possible to obtain a release time of the active ingredient comprised between 3 and 30 minutes and an absolute bioavailability greater than 25%. These compositions have a slow erosion release of agomelatine and are suitable for the treatment of major depression, seasonal affective disorder, generalized anxiety disorder, obsessional compulsive disorder, bipolar disorders, sleep disorders, cardiovascular pathologies, pathologies of the digestive system, insomnia and fatigue due to jet-lag, appetite disorders and obesity, and any pathology associated with deregulation of circadian rhythms.
