The present invention features an anti-rotation instrument system which could be applied/used in all health professions such as medical, dental, and any other specialties. The system includes an anti-rotation instrument device comprising a main handle, a first removable hand grip and a first instrumental tip. The first removable hand grip is attached to a first female screw cavity disposed on the main handle. One end of the instrumental tip passes through a channel disposed within first hand grip with an anti-rotation key disposed on the instrumental tip securely reside within a dent disposed on the distal end of the first removable hand grip and the threading disposed on the end of the instrumental tip is subsequently screwed into the first female screw cavity of the main handle such that the first hand grip is tightly sandwiched between the first instrumental tip and main body.
