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Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
专利权人:
TEVA PHARMACEUTICAL INDUSTRIES LTD.
发明人:
TCHELET AMIR,MACCIARDI FABIO,LEVY JOSEPH
申请号:
NZ62425812
公开号:
NZ624258A
申请日:
2012.10.09
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
A method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier is disclosed comprising the step of determining the genotype of the subject at one or more single nucleotide polymorphisms (SNPs), identifying the subject as a predicted responder or non-responder to glatiramer acetate based on the determined SNP genotype, and administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the subject only if the subject is identified as a predicted responder to glatiramer acetate.
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