A tissue resection hood and related method of use for resecting the tissue are described. The tissue resection hood may include a distal end portion having an opening, a proximal end portion, and a cavity defined between the proximal and distal end portions, wherein the proximal end portion defines an opening configured to couple to an end of a sheath. The tissue resection hood may further include a cutting member configured to traverse the opening in the distal end portion and a mechanism configured to control a dimension of the cavity.
