KARL BRUCE THOR,HIROYUKI KOSHIO,NORIO ASAI,TAISUKE TAKAHASHI,TAKAFUMI SHIMIZU,YASUHITO NAGAI,KEIKO KAWABATA
申请号：
MX2012010570
公开号：
MX2012010570A
申请日:
2011.03.11
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
Disclosed is a compound which is useful as a therapeutic or prophylactic agent for diseases associated with 5-HT2C receptor, especially for urinary incontinence such as stress urinary incontinence, urge urinary incontinence and mixed urinary incontinence, sexual dysfunction such as erectile dysfunction, obesity and the like. Studies have been made on compounds which have a 5-HT2C receptor agonist action and are thus promising as active ingredients of pharmaceutical compositions for the treatment or prophylaxis of urinary incontinence such as stress urinary incontinence, urge urinary incontinence and mixed urinary incontinence, sexual dysfunction such as erectile dysfunction, obesity and the like, and it is confirmed that a specific benzazepine compound has an excellent 5-HT2C receptor agonist action. The benzazepine compound has a 5-HT2C receptor agonist action and can be used as a therapeutic or prophylactic agent for diseases associated with 5-HT2C receptor, especially for urinary incontinence such as stress urinary incontinence, urge urinary incontinence and mixed urinary incontinence, sexual dysfunction such as erectile dysfunction, obesity and the like.Se describe un compuesto que es útil como un agente terapéutico o profiláctico para enfermedades asociadas con el receptor 5-HT2C, especialmente para incontinencia urinaria, tal como incontinencia urinaria de esfuerzo, incontinencia urinaria de urgencia e incontinencia urinaria mixta, disfunción sexual, tal como disfunción eréctil, obesidad y similares. Se han realizado estudios con respecto a los compuestos que tienen una acción agonista del receptor 5-HT2C y son así prometedores como ingredientes activos de composiciones farmacéuticas para el tratamiento o profilaxis de incontinencia urinaria, tal como incontinencia urinaria por estrés, incontinencia urinaria de urgencia e incontinencia urinaria mixta, disfunción sexual tal como disfunción eréctil, obesidad y similares, y se confirma que un compuesto de benzaze
