Rudolf Karl Braun;Katherine Lathrop Knight;Robert Love;Makio Iwashima;Perianna Sethupathi
发明人:
Makio Iwashima,Robert Love,Rudolf Karl Braun,Perianna Sethupathi,Katherine Lathrop Knight
申请号：
US12730701
公开号：
US09029139B2
申请日:
2010.03.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods for generating and using omentum cells, and particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, and immune modulation treatments such as suppression of immune responses and inflammation and prevention of tissue fibrosis. According to one aspect, a medical procedure is performed on a patient that involves harvesting omental tissue from the patient, and then transferring the omental tissue to an organ of the patient. At least a portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. Alternatively, the transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing at least a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.
