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含有碳酸鹽之口腔內崩解錠劑用組成物及口腔內崩解錠劑
专利权人:
DAICEL CORPORATION
发明人:
HIRAMURA, TAKAHIRO,平邑隆弘,ITAYA, SAE,板谷左枝,OKABAYASHI, TOMOHITO,冈林智仁,岡林智仁,SAKAGUCHI, ANAN,坂口阿南
申请号:
TW103142714
公开号:
TW201609193A
申请日:
2014.12.09
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The purpose of the present invention is to provide an intraorally disintegrating tablet that has excellent tablet hardness and disintegration properties even if containing a large amount of medicinal ingredient, and the like. A composition for an intraorally disintegrating tablet, said composition comprising a disintegrating granular composition that is produced by at least a two-step granulation method and a hydrogencarbonate; an intraorally disintegrating tablet containing a medicinal ingredient that has a partition coefficient of -6.0 to 10.0, in particular, the aforesaid intraorally disintegrating tablet wherein the disintegrating granular composition contains acid-type carboxymethylcellulose, the tablet hardness is 30 to 150 N, and the disintegration time in water is 10 to 25 sec; and the like.本發明之課題在於提供一種即便藥效成分之含量較高,亦具有優異之錠劑硬度及崩解性之口腔內崩解錠劑等。本發明係一種含有具有以至少二階段之造粒法製造之崩解性粒子組成物及碳酸氫鹽之口腔內崩解錠劑用組成物,並且進而含有分配係數為-6.0~10.0之藥效成分的口腔內崩解錠劑,尤其是一種崩解性粒子組成物含有酸型羧甲基纖維素,錠劑硬度為30~150N,水中崩解時間為10~25秒的該口腔內崩解錠劑。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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