PROBLEM TO BE SOLVED: To provide intraorally disintegrating tablets and the like having excellent tablet hardness and disintegratability despite containing a high amount of a medical ingredient.SOLUTION: The present invention relates to a composition for intraorally disintegrating tablets containing hydrogen carbonate and a disintegrable particle composition produced by a granulation method comprising at least two steps, and further an intraorally disintegrating tablet containing a medical ingredient having a partition coefficient of -6.0 to 10.0, particularly, containing a disintegrable particle composition containing acid type carboxymethyl cellulose, wherein the tablet hardness is 30 to 150 N, and the disintegration time in water is 10 to 25 seconds.SELECTED DRAWING: Figure 1【課題】薬効成分の含量が高くとも、優れた錠剤硬度と崩壊性を有する口腔内崩壊錠剤等を提供すること。【解決手段】少なくとも二段階の造粒法で製造された崩壊性粒子組成物及び炭酸水素塩を含む口腔内崩壊錠剤用組成物、並びに、更に分配係数が－６．０～１０．０である薬効成分を含む口腔内崩壊錠剤、特に、崩壊性粒子組成物が酸型カルボキシメチルセルロースを含み、錠剤硬度が３０～１５０Nであり、水中崩壊時間が１０～２５秒であるような該口腔内崩壊錠剤。【選択図】図１
