KOREA RESEARCH INSTITUTE OF BIO SCIENCE AND BIOTECHNOLOGY;ENZYCHEM LIFESCIENCES CORPORATION
发明人:
Sei-Ryang OH,Kyung Seop AHN,Su Ui LEE,In Sik SHIN,Ok-Kyoung KWON,Seung Hyung KIM,Chan Mi CHUN,Tae-Suk LEE,Yong-Hae HAN,Ki Young SOHN,JongKoo KANG,Hye Kyung KIM
申请号：
US15857933
公开号：
US20180280336A1
申请日:
2017.12.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
