UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6);ECOLE PRATIQUE DES HAUTES ETUDES;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
NASSIF, NADINE,GOBEAUX, FREDERIC,GIRAUD GUILLE, MARIE MADELEINE,MOSSER, GERVAISE
申请号：
CA2729594
公开号：
CA2729594C
申请日:
2009.06.26
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to a material that can be used as a bone substitute and a process for its preparation. The material comprises an organic phase (I) comprising striated collagen fibrils consisting of triple collagen I helices, said fibrils being ordered at a long distance in a 3D geometry associating aligned domains and cholesteric domains, as well as isotropic domains where they are not ordered； and a mineral phase (II) comprising apatite crystals of hexagonal crystalline structure, 6 / m gap group, comprising at least calcium ions and phosphate ions； the axis c of said apatite crystals of the mineral phase is co-aligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content within the material is at least 75 mg / cm3. The process for preparing the material consists in preparing an initial acidic aqueous solution of collagen precursor of the organic phase (I), and at least one aqueous solution of precursors of the mineral phase (II) and in causing the collagen to precipitate by raising the pH to a value of at least 7. According to this method: the concentration of collagen within the acidic aqueous solution is at least 75 mg / ml and remains constant during said rise in pH； the precursors of the mineral phase comprise at least one calcium salt and at least one phosphate salt； the precipitation of the mineral phase (II) is carried out by contacting the solution of precursors of the mineral phase with the organic phase (I), said contacting being carried out before or after the precipitation of said organic phase (I) .L'invention concerne un matériau utilisable comme substitut osseux et unprocédé pour sa préparation. Le matériaucomprend une phase organique (I) comprenant des fibrilles striées de collagèneconstituées par des triples hélices de collagène I,lesdites fibrilles étant ordonnées à grande distance selon une géométrie 3Dassociant des domaines alignés et des domainescholestériques, ainsi
