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Material biológico adecuado para la terapia de la osteoartrosis, el daño de ligamento y para el tratamiento de trastornos articulares
专利权人:
FIDIA FARMACEUTICI S.P.A.
发明人:
CALLEGARO, LANFRANCO,ZANELLATO, ANNA MARIA
申请号:
ES10729841
公开号:
ES2421300T3
申请日:
2010.06.29
申请国别(地区):
ES
年份:
2013
代理人:
摘要:
A biological material comprising: a) a Liquid Vehicle composed of a viscous solution that contains at least a natural polysaccharide and \/ or semisynthetic and has a Dynamic viscosity measured at 20c and a shear rate d = 350 s-1, between 0.1 and 0.25 Pa.s (100 and 250 cpoise) and \/ or a kinematic viscosity between 0.99 x 10 - 4 and 2.48 x 10 - 4 m \/ s (99 and 248 CST) measured in the same conditions (b) a Crop or extemporaneous preparation of mesenchymal stem cells, and \/ or (c) a platelet rich plasma Product where the viscous solution of component (a) is selected from the group consisting of: i) a Solution aqueous A Hyaluronic acid or a pharmaceutically acceptable salts thereof, preferably sodium saltWith an average Molecular Weight of between 450 and 730 kDa in a concentration between 5 and 15 mg \/ ml, (ii) an aqueous solution of a Hyaluronic acid or a pharmaceutically acceptable salts thereof, preferably sodium salt, with an average Molecular Weight from ent RE 1000 and 1800 kDa measured after sterilizationAt a concentration of between 2 and 12 mg \/ ml (iii) an aqueous solution of the octilamida Hyaluronic acid, with an average Molecular Weight of between 450 and 730 kDa, at a concentration of between 1 and 10 mg \/ ml (iv) an aqueous solution of the acid hexadecilamida HI Alur\u00f3nico, with an average Molecular Weight within the range of 450 to 730 kDa.In a Concentration range between 0.2 and 1.5 mg \/ ml.Un material biológico que comprende: a) un vehículo líquido compuesto por una solución viscosa que contiene al menos un polisacárido natural y/o semisintético y que tiene una viscosidad dinámica medida a 20 °C y a una velocidad de cizallamiento de D >= 350 s-1, comprendida entre 0.1 y 0.25 Pa.s (100 y 250 cPoise) y/o una viscosidad cinemática comprendida entre 0.99 x 10-4 y 2.48 x 10-4 m2/s (99 y 248 cSt) medida en las mismas condiciones b) un cultivo o una preparación extemporánea de células madre mesenquimales, y/o c) un hemoderivado rico en plaquetas
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