ROSS, BRUCE S.,SOFIA, MICHAEL JOSEPH,PAMULAPATI, GANAPATI REDDY,RACHAKONDA, SUGUNA,ZHANG, HAI-REN,CHUN, BYOUNG-KWON,WANG, PEIYUAN
申请号：
CA2915187
公开号：
CA2915187C
申请日:
2010.05.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein are processes for preparing a compound represented by formula 4 and which comprises: a) reacting an isopropyl-alanate, A, a di-X'-phenylphosphate, B, 2'-deoxy-2'-fluoro-2'-C-methyluridine, 3, and a base to obtain a first mixture comprising 4, or the phosphorous-based diastereomer thereof, b) reacting the first mixture with a protecting compound to obtain a second mixture comprising 4, or the phosphorous-based diastereomer thereof, and a protected side product, wherein the protecting compound is t-butyl-dimethyl-silyl-chloride； and c) subjecting the second mixture to crystallization, chromatography, or extraction in order to obtain 4, or the phosphorous-based diastereomer thereof.
