Gong Chen,Ziyuan Guo,Zheng Wu,Zifei Pei,Yuchen Chen
申请号：
US15436275
公开号：
US20170239373A1
申请日:
2017.02.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid encoding a Dlx2 polypeptide to trigger glial cells (e.g., NG2 glial cells or astrocytes) within the brain (e.g., striatum) into forming GABAergic neurons (e.g., neurons resembling medium spiny neurons such as DARPP32-positive GABAergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided.
