Matthew J. Whitters;Joann Witek;Viia Valge-Archer;Mary Collins;Andrew James Williams;Deborah A. Young
发明人:
Viia Valge-Archer,Andrew James Williams,Deborah A. Young,Matthew J. Whitters,Mary Collins,Joann Witek
申请号：
US12353812
公开号：
US08143385B2
申请日:
2009.01.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
