Use of an MTP inhibitor in the manufacture of a medicament for the treatment of a subject suffering from a disorder associated with hyperlipidemia and / or hypercholesterolemia, wherein said treatment comprises the said administration subject to at least three doses of said MTP inhibitor which Increase gradually.Uso de un inhibidor de MTP en la fabricación de un medicamento para eltratamiento de un sujeto que padece un trastorno asociado a la hiperlipidemia y/ohipercolesterolemia, en el que dicho tratamiento comprende la administración adicho sujeto de al menos tres dosis de dicho inhibidor de MTP que aumentangradualmente.