KNOCK-OUT MOUSE, METHOD OF SCREENING MATERIAL SUPPRESSING MESIAL TEMPORAL LOBE EPILEPSY, AND METHOD OF SELECTING TECHNIQUE FOR SUPPRESSING MESIAL TEMPORAL LOBE EPILEPSY

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专利权人:

National University Corporation Nagoya University

发明人:

ASAI Masato,TAKAHASHI Masahide,ASAI Naoya,ENOMOTO Atsushi,UCHIYAMA Kozo

申请号：

EP15851535

公开号：

EP3207795A4

申请日:

2015.10.13

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Provided are a knock-out mouse, a method of screening a material suppressing mesial temporal lobe epilepsy, and a method of selecting a technique for suppressing mesial temporal lobe epilepsy. This knock-out mouse is a mouse, which is 30 days old or more, has lost the function of the Gridin gene at least in the nervous tissue, and also exhibits the phenotypes of (1), (2) and (3) below. (1) Hippocampal sclerosis should be exhibited. (2) Brain damage other than hippocampus should be limited. (3) Auto epilepsy which may be derived from hippocampus should be exhibited.

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中国工程科技知识中心

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