Useful yamanoimo course (Dioscoreaceae) the medicine composition and the food composition which include the extract, and the said extract of the plant are offered to the prevention or remedy of peripheral nervous obstacle. Furthermore yamanoimo course (Dioscoreaceae) the chemical compound which is separated from the extract of the plant is included, the useful medicine composition and the food composition are offered to the prevention or remedy of peripheral nervous obstacle.末梢神経障害の予防または治療に有用なヤマノイモ科(Dioscoreaceae)植物の抽出物、及び該抽出物を含む医薬組成物並びに食品組成物が提供される。さらにヤマノイモ科(Dioscoreaceae)植物の抽出物から分離された化合物を含む、末梢神経障害の予防または治療に有用な医薬組成物並びに食品組成物が提供される。