David Kucera,Gregory J. Haley,Erik J. Rueden,Tingman Wang,Fritz Blatter,Martin Viertelhaus
申请号：
MOI000600
公开号：
MOI000600B
申请日:
2007.10.17
申请国别(地区):
MO
年份:
2015
代理人:
摘要：
This application involves the simultaneously tosilate of [4,5-d] pyrimid-2-one and its applications in the treatment such as illness of virus infection, tumour and cancer of 5- amino -3 (2'-O- acetyl group -3'- deoxidation-β-D-RIBOSE base) -3H- thiazole. Further disclose preparation 5- amino -3 (2'-O- acetyl group -3'- deoxidation-β-D-RIBOSE base) -3H- thiazole simultaneously [4； 5-d] pyrimid-2-one tosilate method； and the method for production furans sugar compounds； the furans sugar compounds are with what preparation of pharmaceutical compounds； such as the useful intermediates of 5- amino -3 (2'-O- acetyl group -3'- deoxidation-β-D-RIBOSE base) -3H- thiazole simultaneously tosilate of [4,5-d] pyrimid-2-one etc..本申請涉及5-氨基-3(2'-O-乙酰基-3'-脫氧-β-D-呋喃核糖基)-3H-噻唑並[4,5-d]嘧啶-2-酮的對甲苯磺酸鹽及其在治療諸如病毒感染、腫瘤和癌症的病症中的應用。還揭示了製備5-氨基-3(2'-O-乙酰基-3'-脫氧-β-D-呋喃核糖基)-3H-噻唑並[4,5-d]嘧啶-2-酮的對甲苯磺酸鹽的方法，以及生產呋喃糖化合物的方法，所述呋喃糖化合物是用於製備藥物化合物，如5-氨基-3(2'-O-乙酰基-3'-脫氧-β-D-呋喃核糖基)-3H-噻唑並[4,5-d]嘧啶-2-酮的對甲苯磺酸鹽等的有用中間體。
