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METHODS AND COMPOSITIONS FOR PROMOTING GLUCOSE HOMEOSTASIS
专利权人:
CHILDRENS MEDICAL CENTER CORPORATION
发明人:
OZCAN, UMUT,LEE, JAEMIN
申请号:
CA2846845
公开号:
CA2846845A1
申请日:
2012.08.30
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
A method of reducing blood glucose in a subject has been developed. In preferred embodiments, the method involves administering to the subject a specific activator of endogenous rnitogen-activated protein kinase kinase 6 (MKK3), rnitogen-activated protein kinase kinase 6 (MKK4), rnitogen-activated protein kinase kinase 6 (MKK6), p38 rnitogen-activated protein kinase (p38MAPK), rnitogen-activated kinase-activated protein kinase 2 (MK2), or a combination thereof, in an effective amount to reduce blood glucose in a subject. In other embodiments, the method involves administering to the subject a specific activator to increase X-box binding protein 1 (XBP1) phosphorylation on Thr48 and Ser61 in an effective amount to reduce blood glucose in the subject. Methods of identifying agents for reducing blood glucose in a subject are also provided.
来源网站:
中国工程科技知识中心
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