[Problem] To provide an anti-human CD73 antibody which is potentiated compared with the conventional antibodies and has an ability to recover a suppressed function of a human T cell which is suppressed in an AMP-dependent manner. [Solution] Provided is an anti-human CD73 antibody containing: a heavy-chain variable region which contains CDR1 comprising an amino acid sequence composed of amino acid residues lying between position-31 to position-35 in SEQ ID NO: 2, CDR2 comprising an amino acid sequence composed of amino acid residues lying between position-50 to position-66 in SEQ ID NO: 2 and CDR3 comprising an amino acid sequence composed of amino acid residues lying between position-99 to position-112 in SEQ ID NO: 2； and a light-chain variable region which contains CDR1 comprising an amino acid sequence composed of amino acid residues lying between position-24 to position-34 in SEQ ID NO: 4, CDR2 comprising an amino acid sequence composed of amino acid residues lying between position-50 to position-56 in SEQ ID NO: 4, and CDR3 comprising an amino acid sequence composed of amino acid residues lying between position-89 to position-98 in SEQ ID NO: 4.Problema Se provee un anticuerpo anti CD73 humana mejorado en comparación con el anticuerpo de la técnica previa y que tiene la capacidad de recuperar las funciones de las células T suprimidas de manera dependiente de AMP. Medios de solución Se provee un anticuerpo anti CD73 humana que comprende una región variable de cadena pesada que comprende la CDR1 que consiste en la secuencia de aminoácidos de los números de aminoácidos 31 a 35 de la SEQ ID NO: 2, la CDR2 que consiste en la secuencia de aminoácidos de los número de aminoácidos 50 a 66 de la SEQ ID NO: 2, y la CDR3 que consiste en la secuencia de aminoácidos de los números de aminoácidos 99 a 112 de la SEQ ID NO: 2, y una región variable de cadena ligera que comprende la CDR1 que consiste en la secuencia de aminoácidos de los números de aminoácidos 24 a 34 de la SEQ
